Con il presente documento, ai sensi degli artt. 13 e 122 del D. Lgs. 196/2003 (“codice privacy”), nonché in base a quanto previsto dal Provvedimento generale del Garante privacy dell’8 maggio 2014, ISayBlog titolare del trattamento, fornisce gli utenti del sito alcune informazioni relative ai cookie utilizzati.
Cosa sono
Un “cookie” è un piccolo file di testo creato sul computer dell’utente nel momento in cui questo accede ad un determinato sito, con lo scopo di immagazzinare informazioni sulla visita, come la lingua preferita e altre impostazioni. Ciò può facilitare la visita successiva e aumentare l’utilità del sito. Per questo motivo i cookie svolgono un ruolo importante.
I cookie sono inviati al browser dell’utente (Internet Explorer, Mozilla Firefox, Google Chrome, ecc.) dal sito web visitato, in particolare dal server web (ovvero il computer sul quale è in esecuzione il sito web). Nel corso della navigazione l’utente potrebbe ricevere anche cookie di siti diversi (di “terze parti”), impostati direttamente da gestori di detti siti web e utilizzati per le finalità e secondo le modalità da questi definiti.
Tipologie di cookie utilizzati in questo sito web
Cookie del Titolare
Il sito utilizza solo cookie tecnici, rispetto ai quali, ai sensi dell’art. 122 del codice privacy e del Provvedimento del Garante dell’8 maggio 2014, non è richiesto alcun consenso da parte dell’interessato. Più precisamente il sito utilizza:
– cookie tecnici strettamente necessari per consentire la navigazione da parte dell’utente, di seguito indicati nel dettaglio
In assenza di tali cookie, il sito web non potrebbe funzionare correttamente.
– cookie tecnici che agevolano la navigazione dell’utente, di seguito indicati nel dettaglio
Cookie di terze parti
Attraverso il sito https://www.politicalive.com/ sono installati alcuni cookie di terze parti, anche profilanti, che si attivano cliccando “ok” sul banner.
Si riportano nel dettaglio i singoli cookie di terze parti, nonché i link attraverso i quali l’utente può ricevere maggiori informazioni e richiedere la disattivazione dei cookie.
Nielsen: https://priv-policy.imrworldwide.com/priv/browser/it/it/optout.htm
Triboo: https://cookie-siti-in-concessione.triboomedia.it/
Google Analytics
Il Sito utilizza Google Analytics. Si tratta di un servizio di analisi web fornito da Google Inc. (“Google”) che utilizza dei cookie che vengono depositati sul computer dell’utente per consentire analisi statistiche in forma aggregata in ordine all’utilizzo del sito web visitato.
I Dati generati da Google Analytics sono conservati da Google così come indicato nella Informativa reperibile al seguente link: https://developers.google.com/analytics/devguides/collection/analyticsjs/cookie-usage
Per consultare l’informativa privacy della società Google Inc., titolare autonomo del trattamento dei dati relativi al servizio Google Analytics, si rinvia al sito internet http://www.google.com/intl/en/analytics/privacyoverview.html
Al seguente link https://tools.google.com/dlpage/gaoptout è inoltre reso disponibile da Google il componente aggiuntivo del browser per la disattivazione di Google Analytics.
Monitoraggio conversioni di Google AdWords (Google Inc.)
E’ un servizio di statistiche fornito da Google Inc. che collega le azioni compiute dagli utenti di questo sito ai dati provenienti dal network di annunci Google AdWords.
Dati personali raccolti: cookie e dati di utilizzo.
Per maggiori informazioni: Privacy Policy
Pubblicità
Questi servizi consentono di utilizzare i dati dell’utente per finalità di comunicazione commerciale in diverse forme pubblicitarie, quali il banner, anche in relazione agli interessi dell’utente e potrebbero utilizzare Cookie per identificare l’utente al fine di visualizzare annunci pubblicitari personalizzati in base agli interessi e al comportamento dell’utente stesso, rilevati anche al di fuori di questo sito.
Per avere maggiori informazioni in merito, ti suggeriamo di verificare le informative privacy dei rispettivi servizi.
Social Buttons
I Social buttons sono quei particolari “pulsanti” presenti sul sito che raffigurano le icone di social network (esempio, Facebook e Twitter) e consentono agli utenti che stanno navigando di interagire con un “click” direttamente con i social network.
I social buttons utilizzati dal sito nella pagina “Contatti” e nel footer della pagina, nell’area dedicata alla pubblicazione dei dati societari, sono dei link che rinviano agli account del Titolare sui social network raffigurati. Tramite l’utilizzo di tali pulsanti non sono pertanto installati cookie di terze parti.
I social buttons utilizzati invece nella pagina “Blog” consentono al social network cui l’icona si riferisce di acquisisce i dati relativi alla visita. Tramite l’utilizzo di tali pulsanti sono pertanto installati cookie di terze parti, anche profilanti. Il sito non condivide però alcuna informazione di navigazione o dato dell’utente acquisiti attraverso il proprio sito con i social network accessibili grazie ai Social buttons.
Si riportano i link ove l’utente può prendere visione dell’informativa privacy relativa alla gestione dei dati da parte dei Social cui i pulsanti rinviano:
https://support.twitter.com/articles/20170519-uso-dei-cookie-e-di-altre-tecnologie-simili-da-parte-di-twitter
https://www.facebook.com/help/cookies
https://www.linkedin.com/legal/cookie_policy
Modalità del trattamento
Il trattamento viene effettuato con strumenti automatizzati dal Titolare. Non viene effettuata alcuna diffusione o comunicazione.
Conferimento dei dati
Fatta eccezione per i cookie tecnici, il conferimento dei dati è rimesso alla volontà dell’interessato che decida di navigare sul sito dopo aver preso visione dell’informativa breve contenuta nell’apposito banner e/o di usufruire dei servizi che richiedano l’installazione di cookie (così per la condivisione dei contenuti tramite Add This).
L’interessato può evitare l’installazione dei cookie mantenendo il banner (Astenendosi dal chiuderlo cliccando sul tasto “OK”) nonché attraverso apposite funzioni disponibili sul proprio browser.
Disabilitazione dei cookie
Fermo restando quanto sopra indicato in ordine ai cookie strettamente necessari alla navigazione, l’utente può eliminare gli altri cookie attraverso la funzionalità a tal fine messa a disposizione dal Titolare tramite la presente informativa oppure direttamente tramite il proprio browser.
Ciascun browser presenta procedure diverse per la gestione delle impostazioni. L’utente può ottenere istruzioni specifiche attraverso i link sottostanti.
Microsoft Windows Explorer
Google Chrome
Mozilla Firefox
Apple Safari
La disattivazione dei cookie di terze parti è inoltre possibile attraverso le modalità rese disponibili direttamente dalla società terza titolare per detto trattamento, come indicato ai link riportati nel paragrafo “cookie di terze parti”.
Per avere informazioni sui cookie archiviati sul proprio terminale e disattivarli singolarmente si rinvia al link: http://www.youronlinechoices.com/it/le-tue-scelte
Diritti dell’interessato
Art. 7 D. Lgs. 196/2003
1. L’interessato ha diritto di ottenere la conferma dell’esistenza o meno di dati personali che lo riguardano, anche se non ancora registrati, e la loro comunicazione in forma intelligibile.
2. L’interessato ha diritto di ottenere l’indicazione:
a) dell’origine dei dati personali;
b) delle finalità e modalità del trattamento;
c) della logica applicata in caso di trattamento effettuato con l’ausilio di strumenti elettronici;
d) degli estremi identificativi del titolare, dei responsabili e del rappresentante designato ai sensi dell’articolo 5, comma 2;
e) dei soggetti o delle categorie di soggetti ai quali i dati personali possono essere comunicati o che possono venirne a conoscenza in qualità di rappresentante designato nel territorio dello Stato, di responsabili o incaricati.
3. L’interessato ha diritto di ottenere:
a) l’aggiornamento, la rettificazione ovvero, quando vi ha interesse, l’integrazione dei dati;
b) la cancellazione, la trasformazione in forma anonima o il blocco dei dati trattati in violazione di legge, compresi quelli di cui non è necessaria la conservazione in relazione agli scopi per i quali i dati sono stati raccolti o successivamente trattati;
c) l’attestazione che le operazioni di cui alle lettere a) e b) sono state portate a conoscenza, anche per quanto riguarda il loro contenuto, di coloro ai quali i dati sono stati comunicati o diffusi, eccettuato il caso in cui tale adempimento si rivela impossibile o comporta un impiego di mezzi manifestamente sproporzionato rispetto al diritto tutelato.
4. L’interessato ha diritto di opporsi, in tutto o in parte:
a) per motivi legittimi al trattamento dei dati personali che lo riguardano, ancorché pertinenti allo scopo della raccolta;
b) al trattamento dei dati personali che lo riguardano a fini di invio di materiale pubblicitario o di vendita diretta o per il compimento di ricerche di mercato o di comunicazione commerciale.
Titolare
Il titolare del trattamento è ISayBlog
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Reger et al. [116] conducted research study to see if providing insulin right into the mind of people with Alzheimer’s illness or amnestic moderate cognitive disability (MCI) would boost memory without raising plasma insulin degrees.
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Thus, substitute of these solvents is most likely to make peptide synthesis greener and likewise may minimize the required solvent quantities and promote solvent recycling which would inevitably result in inexpensive peptide synthesis. On the various other hand, liposomes and emulsions have a smaller sized bit dimension, which favors their absorption and the release of peptides. Peptide encapsulation is a highly effective technique for protecting peptide security and biological task, although the effectiveness of this strategy additionally varies significantly according to the wall materials employed. In recent times, the event of a wide array of drug-resistant illness has actually caused a rise in interest in alternative treatments. Peptide-based medications as an alternating therapy hold scientists’ interest in various healing fields such as neurology, dermatology, oncology, metabolic illness, etc.
Popular drugs for nasal delivery are antihistamines and corticosteroids being the first-line medicines to treat seasonal rhinitis and nasal blockage based upon allergies or infections [14] Topically acting drugs offer advantages in these indications given that they have a quick onset. Further, antihistamines and corticosteroids have as topically acting drugs a low systemic bioavailability and for this reason cause much less adverse side effects and no CNS results. Compared with oral application, the IN administration of these drugs requires lower doses [113, 114] The role of histamines as mediators for allergic rhinitis has been known considering that the early twentieth century.
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As a result, in most cases, the medication focus in the brain is not adequate to create an appropriate healing result. Cerebrospinal-fluid (CSF) shots have been the most extensively tried approach medically to supply drugs to the mind by bypassing the BBB (Pardridge 2020). However, the shot of a drug right into the CSF restricts medicine infiltration right into the mind. parenchyma due to the fact that the CSF is quickly eliminated from the brain right into the blood (Pardridge 2020). Therefore, CSF injections of medications were reported to be equivalent in effectiveness to slow down IV mixtures (Pardridge 2020).
Insulin is administered subcutaneously to the patients with diabetes mellitus who have insulin deficiency. It is dealt with that pharmacokinetic account of intranasal insulin mimics that of the endogenous ‘pulsatile’ insulin (Illum and Davis, 1992; Khafagy et al., 2009a). TCTP-PTD and its variants TCTP-PTD 13, 13M2, in addition to penetratin and its analogs shuffle (R, K solution) 2 and PenetraMax were checked for the systemic shipment of intranasal insulin.
Further, those adverse effects remain in specific pertinent in paediatric medication and for patients with underlying medical problems [228,229,230,231,232] Usefulness of IN drug distribution with systemic diffusion for sedative agents and in emergency scenarios such as epileptic seizures (benzodiazepines) or for opioid overdoses (naloxone) is under investigation. The solution consists of naloxone hydrochloride dihydrate, trisodium citrate dihydrate, sodium chloride, hydrochloric acid, salt hydroxide and cleansed water [126] In clinical tests, its use has actually not just been described as a sedative agent but additionally as an emergency pre-hospital treatment for antiepileptic medicine [114, 127, 128] For the application using the IN path, both indications gain from the rapid start and boosted bioavailability, compared to the dental course and very easy handling, which is in specific relevant for caregivers in pre-clinical circumstances [129, 130]
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When they compared the absorption and distribution accounts of systemic (i.v.) and intranasal (i.n.) administration of insulin in mice, they located that i.v. Insulin was generally found in the systemic blood circulation with mild circulation in the brain (Kamei and Takeda-Morishita, 2015). On the other hand, the intranasal route enhanced the circulation of insulin to the olfactory light bulb with minimal systemic direct exposure of insulin. Course for the similar levels of insulin in the mind, this group utilized L- and D-penetratin to make the most of the nose-to-brain insulin shipment (Kamei and Takeda-Morishita, 2015).
Likewise located is that transepithelial transportation of macromolecules such as protein and peptide therapies is very limited (Bruno et al., 2013). Insulin goes across the BBB via a saturable transportation system, that is influenced by a variety of different factors including, yet not restricted to, the pressure of computer mouse (55) and the mind region (56,57). Concerning 0.05% of an intravenous-injected dosage of insulin is used up per gram of whole mind by the computer mouse (56,58). This is slightly more than that observed after intranasal administration, which peaks at 0.04% at 30 minutes (unpublished data). Despite the fact that insulin is capable of crossing the BBB, peripheral delivery is not a viable restorative alternative as enhancing the degrees of insulin in the blood can generate hypoglycemia. In an additional research study, Zada, et al. [111] targeted N-to-B delivery of thyrotropin-releasing hormonal agent (TRH)( a polypeptide utilized for treating suicidal individuals), utilizing rapid degrading poly( sebacic anhydride) (PSA) NPs.
This revelation unlocked to their use in anti-aging products to target specific skin concerns such as loss of flexibility, wrinkles and dullness. Today, peptides are a foundation in the formulation of lots of premium and clinically progressed skincare products. Peptides play an essential function in promoting the skin’s all-natural fixing devices, thereby revitalizing and restoring aging or harmed skin.
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